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On the amino‐acid‐sequence distribution in benzylglutamate‐methionine copolymers prepared from N ‐carboxyanhydrides
Author(s) -
Hill D. J. T.,
Cardinaux F.,
Scheraga H. A.
Publication year - 1977
Publication title -
biopolymers
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.556
H-Index - 125
eISSN - 1097-0282
pISSN - 0006-3525
DOI - 10.1002/bip.1977.360161110
Subject(s) - cyanogen bromide , chemistry , methionine , copolymer , homoserine , glutamic acid , polymer , amino acid , sequence (biology) , polymer chemistry , polymerization , organic chemistry , peptide sequence , biochemistry , quorum sensing , virulence , gene
Abstract The amino‐acid‐sequence distribution in poly(γ‐benzyl‐ L ‐glutamate, L ‐methionine) prepared by polymerization of the respective N ‐carboxyanhydrides has been investigated. This copolymer was converted first to poly( L ‐glutamic acid, L ‐methionine), which was subsequently cleaved by treatment with cyanogen bromide. The resulting material was fractionated into oligomers of (glutamic acid) n ‐homoserine whose relative molar amounts were determined quantitatively. The results have been compared with those for a random incorporation of the methionine in a γ‐benzylglutamate host polymer. Fairly close agreement has been found.