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Spectroscopic studies on the interaction of Au(III) with nucleosides, nucleotides, and dimethyl phosphate
Author(s) -
Chatterji D.,
Nandi U. S.,
Podder S. K.
Publication year - 1977
Publication title -
biopolymers
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.556
H-Index - 125
eISSN - 1097-0282
pISSN - 0006-3525
DOI - 10.1002/bip.1977.360160904
Subject(s) - chemistry , nucleotide , denticity , phosphate , chelation , stereochemistry , guanosine , inosine , stoichiometry , cytidine , binding site , nuclear magnetic resonance spectroscopy , adenosine , metal , inorganic chemistry , organic chemistry , biochemistry , gene , enzyme
A series of complexes of Au(III) with nucleosides and nucleotides and their methyl derivatives in different stoichiometry have been prepared. Ultraviolet, visible, ir, and nmr studies have been performed to determine the site of binding of these ligands with the metal ion. In (1:4) Au(III): guanosine complex, N 7 is the binding site, whereas at 1:1 complex, a bidentate type of chelation through C 6 O and N 7 is observed. C 6 ‐NH 2 is favored over N 1 as coordinating site at all stoichiometry in the adenosine complex. Inosine binds through N 1 at r = 1. In cytidine, N 1 is the binding site, whereas thymidine reacts only at high pH. In the case of nucleotides a bidentate type of chelation through the phosphate and the ring nitrogen occurs. The phosphate binding ability of Au(III) was further confirmed by studying the interaction of Au(III) with dimethyl phosphate—a conformational analog of the phosphate backbone in DNA chain.