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Reduction of ferriprotoporphyrin IX to the ferroderivative by copoly(4‐vinylpyridine‐ N ‐( p ‐vinylbenzyl)‐3‐carbamoyl‐1,4‐dihydropyridine) in dimethyl sulfoxide
Author(s) -
Tsuchida Eishun,
Hasegawa Etsuo
Publication year - 1977
Publication title -
biopolymers
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.556
H-Index - 125
eISSN - 1097-0282
pISSN - 0006-3525
DOI - 10.1002/bip.1977.360160409
Subject(s) - chemistry , copolymer , dimethyl sulfoxide , pyridine , ferric , dimethylformamide , redox , medicinal chemistry , sulfoxide , polymer chemistry , organic chemistry , polymer , solvent
The copolymer which has both ligand sites (4‐vinylpyridine) and redox sites ( N ‐( p ‐vinylbenzyl)‐3‐carbamoyl‐1,4‐dihydropyridine) was synthesized by the dithionite reduction of the copoly(4‐vinylpyridine‐ N ‐( p ‐vinylbenzyl)‐3‐carbamoylpyridinium chloride) and the reduction of a central ferric‐iron of ferriprotoporphyrin IX by the above‐described copolymer was studied spectrophotometrically in dimethyl sulfoxide. The rate of the reduction by the copolymer was much faster than by N ‐benzyl‐3‐carbamoyl‐1,4‐dihydropyridine. This acceleration by the copolymer could be explained by the intramolecular reduction of ferriprotoporphyrin IX which was coordinated by the pyridine residue of the copolymer.