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Proton magnetic resonance investigation of interactions between L ‐tryptophan and dinucleoside phosphates at low pD
Author(s) -
Kolodny N. H.,
Neville A. C.,
Coleman D. L.,
Zamecnik P. C.
Publication year - 1977
Publication title -
biopolymers
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.556
H-Index - 125
eISSN - 1097-0282
pISSN - 0006-3525
DOI - 10.1002/bip.1977.360160204
Subject(s) - chemistry , protonation , cytidine , tryptophan , stacking , proton magnetic resonance , ring (chemistry) , proton , molecule , nuclear magnetic resonance spectroscopy , crystallography , stereochemistry , resonance (particle physics) , cytosine , nuclear magnetic resonance , ion , dna , biochemistry , amino acid , organic chemistry , enzyme , physics , quantum mechanics , particle physics
Interactions between mononucleoside and dinucleoside phosphates containing adenine and/or cytosine and L ‐tryptophan have been studied at low pD by proton magnetic resonance (pmr) spectroscopy. The results of those studies indicate that, despite extensive protonation of ring positions, and resulting electrostatic repulsion, ring stacking does occur between both like and unlike molecules. Geometries for stacked complexes are proposed and the extent of complex formation between L ‐tryptophan and adenosine or cytidine in 3′ or 5′ esterified positions is discussed qualitatively.