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The β association of ( DL Lys) 10 –( L Val) 20 –( DL Lys) 10 : An nmr study
Author(s) -
Schwartz Arnold M.,
Fasman Gerald D.
Publication year - 1976
Publication title -
biopolymers
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.556
H-Index - 125
eISSN - 1097-0282
pISSN - 0006-3525
DOI - 10.1002/bip.1976.360150711
Subject(s) - chemistry , oligomer , valine , monomer , amide , stereochemistry , crystallography , amino acid , polymer chemistry , polymer , biochemistry , organic chemistry
( DL Lys) 10 –( L Val) 20 –( DL Lys) 10 , a copolymer of a valine block in the β conformation with randomly coiled flanking blocks of lysine [Kubota, S. & Fasman, G. D. (1975) Biopolymers 14 , 605–631], was studied by nuclear magnetic resonance. The peak areas of the NH and CH resonances of valine and lysine are concentration‐dependent with little chemical shift change. A model is presented describing the aggregation of the copolymer. Additional evidence, obtained by monitoring the spin‐lattice relaxation times of amino, amide, γ‐methyl‐valine, and ϵ‐methylene‐lysine, is consistent with the aggregation model. Hydrodynamic studies are presented which show monomer → oligomer aggregation of four or five subunits.