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Co‐oligopeptides of aromatic amino acids and glycine with a variable distance between the aromatic residues. I. Synthesis of co‐oligopeptides of tryptophan and glycine
Author(s) -
Guarnaccia Rocco,
Lorenzi Gian Paolo,
Rizzo Vincenzo,
Luisi Pier Luigi
Publication year - 1975
Publication title -
biopolymers
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.556
H-Index - 125
eISSN - 1097-0282
pISSN - 0006-3525
DOI - 10.1002/bip.1975.360141108
Subject(s) - oligopeptide , chemistry , tryptophan , glycine , amino acid , stereochemistry , aromatic amino acids , organic chemistry , peptide , biochemistry
The preparation of the co‐oligopeptides of the series H‐Gly‐Trp‐(Gly) n ‐Trp‐Gly‐OH ( n = 0, 1, and 2) and of a number of other unprotected co‐oligopeptides of glycine and tryptophan is reported. The syntheses have been carried out by conventional methods, using, in general, N ‐hydroxysuccinimide esters for the coupling steps. All the oligopeptides were obtained after purfication as colorless and crystalline products, and gave only one spot on thin‐layer chromatography. Specfic problems connected with the synthesis and purficiation of optically pure tryptophan‐containing peptides are discussed.