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Investigation of fibrous structures. II. General method for the elucidation of the conformations of the complementary nucleic acids
Author(s) -
Tumanyan V. G.,
Esipova Natalia G.
Publication year - 1975
Publication title -
biopolymers
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.556
H-Index - 125
eISSN - 1097-0282
pISSN - 0006-3525
DOI - 10.1002/bip.1975.360141102
Subject(s) - nucleic acid , chemistry , dna , base pair , helix (gastropod) , computation , nucleic acid structure , base (topology) , stereochemistry , algebraic structure , computational chemistry , rna , biochemistry , pure mathematics , algorithm , mathematics , ecology , mathematical analysis , snail , gene , biology
The problem of deducing the DNA structure with correct base pairing and specific symmetry is formulated in the form of algebraic equations. In this way the number of independent variables determining double‐helix conformation can be reduced from six to four. The effectiveness of the method is illustrated by the computations for A‐DNA and B‐DNA. The method allows one to predict all possible conformations of the complementary nucleic acids.