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Ordered forms of 5′‐8‐aminoguanylic acid
Author(s) -
Hattori Masao,
Frazier Joe,
Miles H. Todd
Publication year - 1975
Publication title -
biopolymers
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.556
H-Index - 125
eISSN - 1097-0282
pISSN - 0006-3525
DOI - 10.1002/bip.1975.360141009
Subject(s) - chemistry , hydrogen bond , crystallography , guanine , nucleotide , planar , stereochemistry , molecule , organic chemistry , biochemistry , computer graphics (images) , computer science , gene
5′‐8NH 2 GMP forms an ordered structure in moderately acid (p D 4.7) solution. We propose for this ordered form a novel hemiprotonated G·G structure with a twofold rotation axis and three hydrogen bonds between each pair of guanine residues. Gel formation does not occur with this nucleotide in either neutral or acid solution. In neutral solution 5′‐8NH 2 GMP also forms a regular, ordered structure, quite different from the acid form and similar to that formed by 5′‐GMP under the same neutral conditions. We suggest that this ordered structure consists of a regularly stacked array of planar tetramers, similar to that proposed for 3′‐GMP at pH 5. 2