A  13 C spin‐lattice relaxation study of dipeptides containing glycine and proline: Mobility of the cyclic proline side chain | Zendy

Fossel E. T. | Zendy; Easwaran K. R. K. | Zendy; Blout E. R. | Zendy

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A 13 C spin‐lattice relaxation study of dipeptides containing glycine and proline: Mobility of the cyclic proline side chain

Author(s) -

Fossel E. T.,

Easwaran K. R. K.,

Blout E. R.

Publication year - 1975

Publication title -

biopolymers

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.556

H-Index - 125

eISSN - 1097-0282

pISSN - 0006-3525

DOI - 10.1002/bip.1975.360140504

Subject(s) - chemistry , proline , glycine , ring (chemistry) , cyclic peptide , stereochemistry , side chain , dipeptide , aqueous solution , relaxation (psychology) , carbon atom , crystallography , spin–lattice relaxation , amino acid , nuclear magnetic resonance , peptide , organic chemistry , polymer , social psychology , psychology , biochemistry , physics , nuclear quadrupole resonance

Molecular dynamics of the cyclic dipeptides cyclo (Gly‐ L ‐Pro), cyclo ‐(L‐Pro‐ L ‐Pro), and cyclo (L‐Pro‐D‐Pro) and the linear dipeptides L‐Pro‐Gly and cis and trans Gly‐ L ‐Pro were studied in neutral aqueous solution by 13 C nuclear magnetic resonance. Spinlattice relaxation times ( T 1 ) were determined for each individual carbon atom. The correlation times, τ, were derived from a semiquantitative analysis of the T 1 data. The correlation times of the proline ring carbons, β, γ, and δ suggest that the cyclic dipeptides have more restriction of conformational freedom in the proline ring than the linear dipeptides. This effect is most pronounced on the γ carbon.

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