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Probability of internal unwinding in the triple helix of collagen
Author(s) -
Schwarz Martin,
Poland Douglas
Publication year - 1974
Publication title -
biopolymers
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.556
H-Index - 125
eISSN - 1097-0282
pISSN - 0006-3525
DOI - 10.1002/bip.1974.360130917
Subject(s) - chemistry , collagen helix , triple helix , covalent bond , sequence (biology) , biophysics , dissociation (chemistry) , helix (gastropod) , crystallography , stereochemistry , biochemistry , ecology , organic chemistry , snail , biology
Helix probability profiles are calculated for collagen models that take into account specific sequence and unwinding from the ends, by internal loops and by chain dissociation, using parameters from a previous study and the technique of the previous paper. 2 An analysis is made of the occurrence of imino acids in known collagen sequences and no significant difference is found from random occurrence. Studies of model sequences generated by random placement of the imino acids show no tendency for collagen to unwind via internal loops even when one end is covalently linked and a loop is permanently nucleated at that end.