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Hydrodynamic properties of a new plasma expander: Polyhydroxyethylaspartamide
Author(s) -
Antoni G.,
Neri P.,
Pedersen T. G.,
Ottesen M.
Publication year - 1974
Publication title -
biopolymers
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.556
H-Index - 125
eISSN - 1097-0282
pISSN - 0006-3525
DOI - 10.1002/bip.1974.360130904
Subject(s) - chemistry , polymer , random coil , viscosity , solvent , exponent , polymerization , intrinsic viscosity , thermodynamics , guanidine , hydrochloride , polymer chemistry , molecule , organic chemistry , crystallography , circular dichroism , linguistics , physics , philosophy
The intrinsic viscosity and molecular weight of several samples of polyhydroxyethylaspartamide with differing degrees of polymerization were determined and related, according to the Mark‐Howink equation. The a exponent is consistent with a random‐coil structure. The average unperturbed dimensions of the polymer, the dimensions in water, and the water–polymer interaction parameter were calculated according to Flory and Fox. The interaction of the polymer with water may explain its good efficacy as a plasma expander, as has previously been demonstrated in biological experiments. The behavior of the molecule in 6 M guanidine hydrochloride solution was also studied: this solvent has a very slight effect on the configuration of the polymer, in contrast with its normal effect on proteins.