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Sequential oligopeptides. Synthesis and characterization of the oligopeptides and a polypeptide with the repeating sequence L ‐norvalyl‐glycyl‐ L ‐proline
Author(s) -
Bonora Gian Maria,
Toniolo Claudio
Publication year - 1974
Publication title -
biopolymers
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.556
H-Index - 125
eISSN - 1097-0282
pISSN - 0006-3525
DOI - 10.1002/bip.1974.360130518
Subject(s) - tripeptide , chemistry , oligopeptide , polymer , sequence (biology) , yield (engineering) , proline , oligomer , peptide synthesis , peptide , stereochemistry , polymer chemistry , amino acid , organic chemistry , biochemistry , materials science , metallurgy
The synthesis and characterization of a series of oligopeptides (from the tripeptide to the octadecapeptide) with the repeating sequence L ‐norvalyl‐glycyl‐ L ‐proline and a polytripeptide with this sequence are reported. The oligomers were synthesized step by step using the mixed anhydride method. All the products were chemically and optically pure. The polymer was prepared by the active ester method, using the p ‐nitrophenyl ester as the polymerizable tripeptide derivative. Good yield of relatively high average molecular‐weight polymer was obtained. In the accompanying paper conformational investigations, both in solution and in the solid state, on the oligomers and the polymer are described.