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The formation of the triple helix in a mixed solution of (Pro‐Pro‐Gly) n and (Pro‐Pro‐Gly) n ′. A model of molecular size recognition
Author(s) -
Suezaki Yukio,
Gō Nobuhiro
Publication year - 1974
Publication title -
biopolymers
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.556
H-Index - 125
eISSN - 1097-0282
pISSN - 0006-3525
DOI - 10.1002/bip.1974.360130508
Subject(s) - triple helix , cooperativity , chemistry , helix (gastropod) , random coil , polymerization , crystallography , chain (unit) , alpha helix , stereochemistry , circular dichroism , polymer , organic chemistry , physics , biochemistry , quantum mechanics , ecology , snail , biology
A theoretical analysis is given of the triple‐helix–random‐coil transition in a mixed solution of poly(Pro‐Pro‐Gly) n with two different but defined degrees of polymerization n and n ′. Because of the highly cooperative nature of this helix–coil transition, each polypeptide chain tends to form a triple helix with other polypeptide chains with the same degree of polymerization (size recognition). Occurrence of triple helices consisting of polypeptide chains with different degrees of polymerization (error in recognition) is studied in detail as a function of the cooperativity, and n and n ′. Implication of this analysis for molecular recognition in general is discussed.