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Binding by derivatives of polyethylenimine: Effects of charge and structure of small molecules
Author(s) -
Johnson Timothy W.,
Klotz Irving M.
Publication year - 1974
Publication title -
biopolymers
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.556
H-Index - 125
eISSN - 1097-0282
pISSN - 0006-3525
DOI - 10.1002/bip.1974.360130414
Subject(s) - polyethylenimine , chemistry , molecule , charge (physics) , small molecule , aqueous solution , combinatorial chemistry , organic molecules , computational chemistry , stereochemistry , organic chemistry , biochemistry , transfection , physics , quantum mechanics , gene
Apolar derivatives of polyethylenimine in aqueous solution have been shown previously to bind organic anions very strongly. These studies have been extended to other charged and noncharged small molecules, as well as to derivatives of polyethyl‐enimine with much reduced positive charge. From these investigations the effects of charge and of structure of the small molecules can be assessed.