Proton magnetic resonance study of complex formation between N 6 ‐methyladenosine and polyuridylic acid | Zendy

Bangerter Benedict W. | Zendy; Modestas Zivile | Zendy

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Proton magnetic resonance study of complex formation between N 6 ‐methyladenosine and polyuridylic acid

Author(s) -

Bangerter Benedict W.,

Modestas Zivile

Publication year - 1974

Publication title -

biopolymers

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.556

H-Index - 125

eISSN - 1097-0282

pISSN - 0006-3525

DOI - 10.1002/bip.1974.360130309

Subject(s) - chemistry , proton magnetic resonance , n6 methyladenosine , stacking , uracil , monomer , hydrogen bond , crystallography , stereochemistry , proton , polymer , nuclear magnetic resonance , molecule , organic chemistry , biochemistry , dna , methyltransferase , physics , quantum mechanics , methylation

The interaction between N 6 ‐methyladenosine and polyuridylic acid in D 2 O solution at neutral pD has been studied as a function of temperature and N 6 ‐methyladenosine concentration by proton magnetic resonance spectroscopy. A rigid double‐stranded 1:1 complex is formed below ∼10°C, involving hydrogen‐bonded N 6 ‐methyladenine:uracil base‐pairing and stacking of the adenine bases. This complex is less stable than the 1:2 complex formed between adenosine and polyU, and involves a more rapid exchange of the monomer between free and polymer‐bound environments.

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