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α‐Glutamyl oligopeptides: Preparation by the solid‐phase method
Author(s) -
Bonora G. M.,
Toniolo C.,
Fontana A.,
Di Bello C.,
Scoffone E.
Publication year - 1974
Publication title -
biopolymers
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.556
H-Index - 125
eISSN - 1097-0282
pISSN - 0006-3525
DOI - 10.1002/bip.1974.360130110
Subject(s) - chemistry , oligopeptide , peptide , chromatography , fractionation , ion exchange , phase (matter) , solid phase synthesis , ion chromatography , amino acid , ion exchange resin , ion , organic chemistry , biochemistry
The synthesis of the oligomeric peptides (Glu) n –Phe(NO 2 )–Phe (up to n = 4) by the solid‐phase method is reported. Fractionation by ion‐exchange column chromatography of the crude materials cleaved from the resin and subsequent amino acid analysis revealed that the desired peptides were obtained, although contaminated by several by‐products whose number depends on the length of peptide chain and on the experimental conditions.