z-logo
Premium
Interaction of metal ions with polynucleotides and related compounds. XXII. Effect of divalent metal ions on the conformational changes of polyribonucleotides
Author(s) -
Shin Yong Ae
Publication year - 1973
Publication title -
biopolymers
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.556
H-Index - 125
eISSN - 1097-0282
pISSN - 0006-3525
DOI - 10.1002/bip.1973.360121103
Subject(s) - polynucleotide , chemistry , divalent , metal ions in aqueous solution , metal , crystallography , ion , nucleotide , stereochemistry , organic chemistry , biochemistry , gene
Changes in the conformation of poly(G), poly(C), poly(U), and poly(I) in the presence of divalent metal ions Mg 2+ , Ca 2+ , Mn 2+ , Co 2+ , Ni 2+ , Cu 2+ , Cd 2+ , and Zn 2+ have been measured by means of ORD and u.v. spectra. Mg 2+ and Ca 2+ ions stabilize helical structures of all the polynucleotides very effectively at concentrations several orders of magnitude lower than the effective concentration of Na + ion. Cu 2+ and Cd 2+ destabilize the helical structure of polynucleotides to form random coils. Zn 2+ , Ni 2+ , Co 2+ , and Mn 2+ ions do not behave in such a clear‐cut manner: they selectively stabilize some ordered structures, while destabilizing others, depending on the ligand strength of the nucleotide base as well as the preferred conformation of that polynucleotide.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here