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Theory of aggregation in solution. I. General equations and application to the stacking of bases, nucleosides, etc.
Author(s) -
Hill Terrell L.,
Chen YiDer
Publication year - 1973
Publication title -
biopolymers
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.556
H-Index - 125
eISSN - 1097-0282
pISSN - 0006-3525
DOI - 10.1002/bip.1973.360120608
Subject(s) - stacking , chemistry , virial coefficient , work (physics) , ideal solution , ideal (ethics) , measure (data warehouse) , thermodynamics , statistical physics , computational chemistry , organic chemistry , physics , computer science , philosophy , epistemology , database
Earlier theoretical work on aggregation in imperfect gases and in solutions of protein molecules is reformulated here in such a way as to be applicable to a number of aggregation systems in solution. The theory is most easily developed for an “osmotic” solution. It is exact, in principle, and in particular does not treat the aggregates as an ideal mixture as is usually done. If osmotic virial coefficients are diffcult to measure in a particular case, it is then necessary to relate these coefficients to properties of the more conventional “constant pressure” solution. An important special case is used as an example in the last three sections: The stacking of bases, nucleosides, etc., is represented by a statistical mecchanical model in which the aggregates resemble vertical stacks of checkers.