Conformational analysis of an ionizable polydipeptide | Zendy

Hiltner W. A. | Zendy; Hopfinger A. J. | Zendy; Walton A. G. | Zendy

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Conformational analysis of an ionizable polydipeptide

Author(s) -

Hiltner W. A.,

Hopfinger A. J.,

Walton A. G.

Publication year - 1973

Publication title -

biopolymers

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.556

H-Index - 125

eISSN - 1097-0282

pISSN - 0006-3525

DOI - 10.1002/bip.1973.360120114

Subject(s) - chemistry , polyglutamic acid , helix (gastropod) , aqueous solution , polymer , degenerate energy levels , crystallography , stereochemistry , computational chemistry , organic chemistry , biochemistry , ecology , physics , quantum mechanics , snail , biology

A semi‐empirical conformational energy calculation has been performed on the ionizable polydipeptide poly(Glu‐Ala). The results indicate that; (1)the ionized polymer assumes the lefthanded extended helix conformation is aqueous solution; (2) the poly(Glu‐Ala) extended helix is less stable than that of polyglutamic acid; (3) the unionized polydipeptide will preferentially assume the “β‐helical” conformation (isolated 2 1 degenerate helix) in aqueous solution. These conclusions are supported by experiment.

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