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Conformational analysis of an ionizable polydipeptide
Author(s) -
Hiltner W. A.,
Hopfinger A. J.,
Walton A. G.
Publication year - 1973
Publication title -
biopolymers
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.556
H-Index - 125
eISSN - 1097-0282
pISSN - 0006-3525
DOI - 10.1002/bip.1973.360120114
Subject(s) - chemistry , polyglutamic acid , helix (gastropod) , aqueous solution , polymer , degenerate energy levels , crystallography , stereochemistry , computational chemistry , organic chemistry , biochemistry , ecology , physics , quantum mechanics , snail , biology
A semi‐empirical conformational energy calculation has been performed on the ionizable polydipeptide poly(Glu‐Ala). The results indicate that; (1)the ionized polymer assumes the lefthanded extended helix conformation is aqueous solution; (2) the poly(Glu‐Ala) extended helix is less stable than that of polyglutamic acid; (3) the unionized polydipeptide will preferentially assume the “β‐helical” conformation (isolated 2 1 degenerate helix) in aqueous solution. These conclusions are supported by experiment.