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Theoretical calculation of the circular dichroism of unordered polypeptide chains
Author(s) -
Ronish E. W.,
Krimm S.
Publication year - 1972
Publication title -
biopolymers
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.556
H-Index - 125
eISSN - 1097-0282
pISSN - 0006-3525
DOI - 10.1002/bip.1972.360110912
Subject(s) - chemistry , polypeptide chain , dipeptide , circular dichroism , chain (unit) , oligopeptide , spectrum (functional analysis) , spectral line , crystallography , stereochemistry , peptide , amino acid , biochemistry , physics , quantum mechanics , astronomy
A calculation has been done of the circular dichroism (CD) spectrum of an unordered polypeptide chain. This has been based on a Boltzmann averaging over a dipeptide conformational CD map. This is shown to be valid by comparing the CD spectra of 28‐mer oligopeptides with those generated by summing dipeptide CD spectra. The calculated CD spectrum of an unordered polypeptide chain is found to agree with the assignment proposed by Tiffany and Krimm from experimental studies.