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Model connective tissue system: The effect of proteoglycans on the distribution of small non‐electrolytes and micro‐ions
Author(s) -
Preston B. N.,
McK. Snowden J.,
Houghton K. T.
Publication year - 1972
Publication title -
biopolymers
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.556
H-Index - 125
eISSN - 1097-0282
pISSN - 0006-3525
DOI - 10.1002/bip.1972.360110811
Subject(s) - chemistry , electrolyte , macromolecule , glycosaminoglycan , ion , fixation (population genetics) , proteoglycan , connective tissue , biophysics , inorganic chemistry , biochemistry , organic chemistry , medicine , electrode , pathology , biology , extracellular matrix , gene
Donnan equilibria between solutions of various carbohydrates polyins and Na ⊕ have been measured by equilibrium dialysis. From the results, estimates have been made of the degree of Na ⊕ fixation by the polyions. Comparison is made between the behavior of the complex proteoglycan macromolecules and their constituent glycosaminoglycans. Attempts to interpret these results and the Na ⊕ activity in saltfree solutions on the parameter of the intercharge distance has been made. By use of studies on carboxymethylcellulose, the relative importance of the carboxyl and of the sulphate ester groups in the Na ⊕ fixation is assessed. The relevance of the measurements to the previously described diffusional effects found in real and model connective tissues is discussed.