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Characterization of two sequential polytripeptides containing glycine and ethyl‐glutamate residues
Author(s) -
Rippon W. Barton,
Chen H. H.,
Anderson J. M.,
Walton A. G.
Publication year - 1972
Publication title -
biopolymers
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.556
H-Index - 125
eISSN - 1097-0282
pISSN - 0006-3525
DOI - 10.1002/bip.1972.360110709
Subject(s) - chemistry , circular dichroism , antiparallel (mathematics) , trifluoroacetic acid , polymer , aqueous solution , crystallography , triple helix , glycine , infrared spectroscopy , polymer chemistry , stereochemistry , amino acid , organic chemistry , biochemistry , physics , quantum mechanics , magnetic field
The polytripeptides poly(glu(OEt)‐gly‐gly) and poly(glu(OEt)‐glu(OEt)‐gly) have been synthesized and characterized using infrared linear dichroism, ultraviolet circular dichroism spectroscopy, and electron microscopy. Both polymers have been obtained in a cross β conformation with antiparallel chains, however, there appear to be significant differences in the stability of this conformation for the two polymers. Poly(glu(OEt)‐gly‐gly) has also been shown to exist in a 3 1 polyglycine II type helix in aqueous solution whereas films cast from this solution appear to be random. Finally this same polymer can be obtained in either a random or an extended form trifluoroacetic acid depending on the nature of the substrate used for film casting.