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The determination of the thermodynamic parameter of the helix‐coil transition of polypeptides by means of dipole moment measurements
Author(s) -
Dufour C.,
Marchal E.
Publication year - 1972
Publication title -
biopolymers
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.556
H-Index - 125
eISSN - 1097-0282
pISSN - 0006-3525
DOI - 10.1002/bip.1972.360110507
Subject(s) - helix (gastropod) , chemistry , dipole , enthalpy , moment (physics) , electromagnetic coil , thermodynamics , transition dipole moment , solvent , crystallography , physics , organic chemistry , classical mechanics , quantum mechanics , ecology , snail , biology
The theoretical change of the mean‐square dipole moment of a polypeptide during the helix‐coil transition is compared with the change in helix content. It is shown that, according to the theory, the determination of the helix initiation parameter σ and the enthalpy of helix formation Δ H can be determined. Experimental data on poly‐benzyl‐ L ‐gluatamate in two different solvent mixtures are given.