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The helix–coil transitions of poly (dA). Poly (dT) and poly (dA‐dT). Poly (dA‐dT)
Author(s) -
Wartell Roger M.
Publication year - 1972
Publication title -
biopolymers
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.556
H-Index - 125
eISSN - 1097-0282
pISSN - 0006-3525
DOI - 10.1002/bip.1972.360110403
Subject(s) - chemistry , exponent , polymer , helix (gastropod) , entropy (arrow of time) , stacking , thermodynamics , loop (graph theory) , electromagnetic coil , crystallography , polymer chemistry , physics , organic chemistry , ecology , philosophy , linguistics , mathematics , combinatorics , quantum mechanics , snail , biology
Abstract Helix–coil transition curves are calculated for poly (dA) poly(dT) and poly (dA‐dT) poly (dA‐dT) using the integral equation approach of Goel and Montroll. 5 The transitions are described by the loop entropy model with the exponent of the loop entropy factor, k , remaining an arbitrary constant. The theoretical calculations are compared with experimental transition curves of the two polymers. Results indicate that the stacking energies for these two polymers differ by about 1 kcal/mole of base pairs. Also, a fit between theory and experiment was not possible for k > 1.70.