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Preferential and absolute interactions of solvent components with proteins in mixed solvent systems
Author(s) -
Inoue Hideo,
Timasheff Serge N.
Publication year - 1972
Publication title -
biopolymers
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.556
H-Index - 125
eISSN - 1097-0282
pISSN - 0006-3525
DOI - 10.1002/bip.1972.360110402
Subject(s) - chemistry , solvent , macromolecule , polar , residue (chemistry) , parallels , component (thermodynamics) , solvent effects , computational chemistry , thermodynamics , organic chemistry , biochemistry , mechanical engineering , physics , astronomy , engineering
An equation is derived relating total and preferential interactions of solvent components with macromolecules in a three‐component system. Application of this equation to literature data shows that binding of non‐polar solvents to proteins parallels the unfolding of the latter. This observation is discussed in terms of local inter‐residue and residue‐solvent interactions.