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A cross‐linked copolypeptide with increased affinity for cations
Author(s) -
Kim Yung D.,
Klotz Irving M.
Publication year - 1972
Publication title -
biopolymers
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.556
H-Index - 125
eISSN - 1097-0282
pISSN - 0006-3525
DOI - 10.1002/bip.1972.360110209
Subject(s) - chemistry , adduct , covalent bond , polymer chemistry , copolymer , avidity , urea , organic chemistry , polymer , antibody , immunology , biology
The copolymer poly Glu 42 Lys 28 Ala 30 was crosslinked by S–S bridges by reaction with butyrothiolactone followed by air oxidation of the mercaptan covalent adduct. The modified copolypeptide was more compact hydrodynamically, more resistant to the structurally disruptive effects of urea, and able to bind dye cations with much increased avidity.
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