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Physicochemical analysis of (Pro‐Pro‐Gly) n with defined molecular weight–temperature dependence of molecular weight in aqueous solution
Author(s) -
Kobayashi Yuji,
Sakai Rume,
Kakiuchi Kinji,
Isemura Toshizo
Publication year - 1970
Publication title -
biopolymers
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.556
H-Index - 125
eISSN - 1097-0282
pISSN - 0006-3525
DOI - 10.1002/bip.1970.360090404
Subject(s) - chemistry , optical rotation , monomer , aqueous solution , polymer , molecule , phase (matter) , function (biology) , phase transition , thermodynamics , analytical chemistry (journal) , crystallography , chromatography , organic chemistry , physics , evolutionary biology , biology
Sequenced polytripeptides, (Pro‐Pro‐Gly) n , ( n = 10, 15, 20), with defined molecular weights were synthesized by the solid‐phase method. Conformational changes of these sample as a function of temperature were studied by measurements of optical rotation and sedimentation equilibrium. The temperature dependence of optical rotation was shown similar to thermal transition of collagen molecule. Each of these polymers existed as a timer at lower temperature. (Pro‐Pro‐Gly) 10 existed as a monomer at higher temperature, and the others were expected to behave analogously.