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Circular dichroism of polynucleotides: A general method applied to dimers
Author(s) -
Johnson W. C.,
Tinoco I.
Publication year - 1969
Publication title -
biopolymers
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.556
H-Index - 125
eISSN - 1097-0282
pISSN - 0006-3525
DOI - 10.1002/bip.1969.360080603
Subject(s) - circular dichroism , degenerate energy levels , polynucleotide , chemistry , perturbation (astronomy) , dichroism , crystallography , optics , physics , quantum mechanics , biochemistry
A method is described which relates the circular dichroism of a polymer to its conformation. The method takes into account near and accidental degeneracies and eliminates the artificial distinction between degenerate and nondegenerate systems. Comparison of this method with perturbation theory indicates that the errors inherent in nondegenerate perturbation theory tend to cancel when a circular dichroism spectrum is calculated. The method is applied to dinucleoside phosphates.