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Circular dichroism of aminoacridines bound to DNA
Author(s) -
Dalgleish D. G.,
Fujita H.,
Peacocke A. R.
Publication year - 1969
Publication title -
biopolymers
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.556
H-Index - 125
eISSN - 1097-0282
pISSN - 0006-3525
DOI - 10.1002/bip.1969.360080506
Subject(s) - chemistry , circular dichroism , proflavine , dna , crystallography , zero (linguistics) , phosphate , stereochemistry , biochemistry , linguistics , philosophy
The binding curves of 1‐, 2‐, 3‐, and 9‐aminoacridine and proflavine on native DNA and the circular dichroism (CD) spectra of the bound cations have been determined under the same conditions. The variation of the CD spectra with the amount ( r ) of aminoacridine bound per DNA phosphorus was of two main kinds: ( 1 ) the rotational strength of those aminoacridines which possess a 3‐amino group depended markedly on r and decreased to relatively small values (or zero) at zero r ; or, ( 2 ) the rotational strength changed relatively little with r and tended to a finite value at zero r . The relevance of these observations is discussed with respect to interelation models of the complexes and with respect to possible explanations of the basis of this induction of optical activity.