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General theoretical approach to the thermodynamic and kinetic properties of cooperative intramolecular transformations of linear biopolymers
Author(s) -
Schwarz Gerhard
Publication year - 1968
Publication title -
biopolymers
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.556
H-Index - 125
eISSN - 1097-0282
pISSN - 0006-3525
DOI - 10.1002/bip.1968.360060610
Subject(s) - chemistry , intramolecular force , cooperativity , thermodynamics , relaxation (psychology) , kinetic energy , ising model , statistical physics , stereochemistry , physics , classical mechanics , psychology , social psychology , biochemistry
A general method to calculate experimentally accessible thermodynamic and kinetic quantities for any type of cooperative transitions is developed. Special attention has been directed to transition curves and mean relaxation times. The procedure is applied to the most general case of nearest‐neighbor cooperativity by using the linear Ising model and the matrix method of evaluation. The various potential types of end effects arid the resulting chain length dependences are discussed in detail. The significance of the theory with respect to the helix‐coil transition of polypeptides as well as to the polyproline I‐II transition is indicated.