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Comparison of several calculations of helix–coil transitions in hetergeneous polymers
Author(s) -
Fink Thomas R.,
Crothers Donald M.
Publication year - 1968
Publication title -
biopolymers
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.556
H-Index - 125
eISSN - 1097-0282
pISSN - 0006-3525
DOI - 10.1002/bip.1968.360060609
Subject(s) - random coil , helix (gastropod) , electromagnetic coil , computation , sequence (biology) , chemistry , range (aeronautics) , statistical physics , polymer , crystallography , physics , algorithm , mathematics , materials science , quantum mechanics , circular dichroism , ecology , biochemistry , organic chemistry , snail , composite material , biology
Abstract Random number methods are used to calculate helix—coil transition curves for the model of a heterogeneous polypeptide of random sequence. These curves are compared with several other calculations. The random number computations confirm the exact calculation of Lehman; among the several approximate calculations examined only that of Fixman and Zeroka agrees closely with results of the random number method over the whole range of conditions considered. Calculations are also reported of the average length of helix and coil sections in a heterogeneous molecule of random sequence which is undergoing the helix‐coil transition.