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Temperature‐dependent properties of dinucleoside phosphates
Author(s) -
Davis Robert C.,
Tinoco Ignacio
Publication year - 1968
Publication title -
biopolymers
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.556
H-Index - 125
eISSN - 1097-0282
pISSN - 0006-3525
DOI - 10.1002/bip.1968.360060206
Subject(s) - chemistry , dimer , salt (chemistry) , proton magnetic resonance , optical rotatory dispersion , solvent , proton , dispersion (optics) , crystallography , nuclear magnetic resonance , organic chemistry , physics , quantum mechanics , circular dichroism
The optical rotatory dispersion, hypochromism, and proton magnetic resonance were measured for a number of dinucleoside phosphates in both dilute salt solutions and in 25.2% LiCl (which freezes below −70°C.) as a function of temperature. Two models for the “disordering” of dinucleoside phosphates: the two‐state model and the oscillating dimer model, are used to analyze the data. Both models fit some of the data, but neither are completely satisfactory. Evidence is given for a dynamic structure of dinucleoside phosphates, in which the bases oscillate with respect to one another, remaining parallel to one another with no solvent in between, even at high temperatures. Implications of this model to the structures of single‐strand sections of RNA's are discussed.