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Volume changes accompanying collagen denaturation
Author(s) -
Christensen R. G.,
Cassel J. M.
Publication year - 1967
Publication title -
biopolymers
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.556
H-Index - 125
eISSN - 1097-0282
pISSN - 0006-3525
DOI - 10.1002/bip.1967.360050802
Subject(s) - chemistry , denaturation (fissile materials) , aqueous solution , volume (thermodynamics) , solvation , polymer , partial specific volume , biophysics , thermodynamics , nuclear chemistry , molecule , biochemistry , organic chemistry , physics , biology , enzyme
A dilatometric technique is employed to measure the volume changes occurring on denaturation of collagen solutions and tendons. Partial specific volumes of tropocollagen are calculated to be 0.686 ml./g. in water and 0.689 ml/g in 0.1 M citrate buffer. From data on non‐aqueous solutions, it is estimated that most of the volume change arises from changes in polymer configuration rather than from changes in solvation.