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Effect of glycyl residues on the stability of the α‐helix
Author(s) -
Fraser R. D. B.,
Harrap B. S.,
Macrae T. P.,
Stewart F. H. C.,
Suzuki E.
Publication year - 1967
Publication title -
biopolymers
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.556
H-Index - 125
eISSN - 1097-0282
pISSN - 0006-3525
DOI - 10.1002/bip.1967.360050303
Subject(s) - chemistry , optical rotatory dispersion , helix (gastropod) , polymer , crystallography , dispersion (optics) , infrared spectroscopy , infrared spectrophotometry , diffraction , spectrophotometry , infrared , stereochemistry , chromatography , circular dichroism , organic chemistry , optics , ecology , physics , snail , biology
A series of polypeptides containing ordered sequences of glyeyl and γ‐ethyl L ‐glutamyl residues has been synthesized. The properties of the polymers were investigated by x‐ray diffraction, infrared spectrophotometry, and optical rotator dispersion, and the results indicate that glycine appreciably reduces the stability of the γ‐ethyl L ‐glutamate helix.