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Circular dichroism measurements of benzyl L ‐aspartate–nitrobenzyl L ‐aspartate copolymers and their use in detecting and characterizing preferred polymer conformations
Author(s) -
Bradley Dan F.,
Goodman Murray,
Felix Arthur,
Records Ruth
Publication year - 1966
Publication title -
biopolymers
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.556
H-Index - 125
eISSN - 1097-0282
pISSN - 0006-3525
DOI - 10.1002/bip.1966.360040602
Subject(s) - circular dichroism , chemistry , pairwise comparison , copolymer , polymer , helix (gastropod) , side chain , crystallography , organic chemistry , mathematics , ecology , statistics , snail , biology
We have examined the nature of the circular dichroism band at 330 mμ for a series of copolymers of β‐ p ‐nitrobenzyl L ‐aspartate with β‐benzyl L ‐aspartate. The circular dichroism band arises from an electronic transition in the nitroaromatic group. In order to interpret the effect quantitatively, we employed a simplified statistical treatment and curve fitting for six copolymers. Both approaches gave consistent results, which indicates that the dichroism comes from pairwise interactions between two nitrobenzyl groups. We constructed a molecular model that meets the constraints and requirements of the analyses developed in this paper. In this model, it is proposed that the main chain forms a right‐handed α‐helix and that nitrobenzyl groups separated by four residues interact with each other.