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Solvent effects in N ‐carboxyanhydride (NCA) polymerization initiated by strong base type initiators
Author(s) -
Cosani A.,
D'este G.,
Peggion E.,
Scoefone E.
Publication year - 1966
Publication title -
biopolymers
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.556
H-Index - 125
eISSN - 1097-0282
pISSN - 0006-3525
DOI - 10.1002/bip.1966.360040509
Subject(s) - chemistry , polymerization , solvent , polymer , dimethylformamide , polymer chemistry , catalysis , base (topology) , precipitation , solvent effects , organic chemistry , mathematical analysis , physics , mathematics , meteorology
The γ‐benzyl‐ L ‐glutamate N ‐carboxyanhydride (NCA) polymerization initialed by diisopropylamine was studied in dimethylformamide (DMF)‐dioxane mixtures of different compositions. It was found that the shape of the conversion versus time plots and the molecular weights of the polymers depend on the solvent composition. Auto‐catalysis is present only when dioxane predominates in the solvent mixtures. Moreover, the molecular weight of the final polymer depends strongly on the precipitation conditions when the polymerization is carried out in DMF.