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Kinetics of synthesis and/or conformational changes of biological macromolecules
Author(s) -
Pipkin A. C.,
Gibbs J. H.
Publication year - 1966
Publication title -
biopolymers
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.556
H-Index - 125
eISSN - 1097-0282
pISSN - 0006-3525
DOI - 10.1002/bip.1966.360040103
Subject(s) - macromolecule , chemistry , kinetics , analogy , thermodynamics , biochemistry , classical mechanics , physics , linguistics , philosophy
The analogy, in both the thermodynamics and the kinetics, of reversible polymerizations on templates (in the case wherein these are catalyzed by exoenzymes) to helix–coil transitions (in the case where these proceed only from one end of each macromolecular chain) is presented. A suggestion, based on this analogy, is made concerning the possible nature of biological control of synthesis of macromolecules (enzyme induction and repression). The equations governing the kinetics of these one‐dimensional cooperative processes are presented and their solutions discussed.