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Anomalous rotatory dispersion of metachromatic mucopolysaccharide‐dye complexes. I. Heparin
Author(s) -
Stone Audrey Larack
Publication year - 1964
Publication title -
biopolymers
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.556
H-Index - 125
eISSN - 1097-0282
pISSN - 0006-3525
DOI - 10.1002/bip.1964.360020403
Subject(s) - metachromasia , chemistry , chromophore , heparin , optical rotatory dispersion , dispersion (optics) , polymer , absorption (acoustics) , polymer chemistry , photochemistry , stereochemistry , organic chemistry , circular dichroism , biochemistry , optics , staining , medicine , physics , pathology
Optical rotatory dispersion measurements on metachromatic heparin:dye complexes have revealed Cotton effects in the absorption region of the hound dye which are dependent upon the “native” integrity of the heparin molecule and upon the dye to site ratio, that is, the dye array. According to the recent ideas concerning induced Cotton effects in external chromophores hound to helical polymers, heparin, a mucopolysaccharide, appears to exhibit helical secondary structure.