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Detection of polypeptide helix‐coil transitions by nuclear magnetic resonance
Author(s) -
Goodman Murray,
Masuda Yukio
Publication year - 1964
Publication title -
biopolymers
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.556
H-Index - 125
eISSN - 1097-0282
pISSN - 0006-3525
DOI - 10.1002/bip.1964.360020202
Subject(s) - trifluoroacetic acid , chemistry , helix (gastropod) , solvent , nuclear magnetic resonance , nuclear magnetic resonance spectroscopy , electromagnetic coil , spectroscopy , high resolution , two dimensional nuclear magnetic resonance spectroscopy , stereochemistry , organic chemistry , ecology , physics , remote sensing , quantum mechanics , geology , snail , electrical engineering , biology , engineering
We have studied the helix coil transition for poly‐γ‐ethyl‐ L ‐glutamate (PELG) in the mixed solvent system: trifluoroacetic acid‐trifluoroethanol by high resolution nuclear magnetic resonance spectroscopy. At 25°, the transition occurs over a range of solvent compositions between 62–64% trifluoroacetic acid. In addition, we have assigned τ‐values to the various types of protons in PKLG.