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External reversible control of recognition behavior of alpha‐peptide ribonucleic acid (α‐PRNA) through anti‐syn orientational switching of the nucleobase induced by borate esterification of the cis ‐2′,3′‐diol
Author(s) -
Wada Takehiko,
Sato Hirofumi,
Inoue Yoshihisa
Publication year - 2004
Publication title -
peptide science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.556
H-Index - 125
eISSN - 1097-0282
pISSN - 0006-3525
DOI - 10.1002/bip.10563
Subject(s) - chemistry , nucleobase , nucleic acid , peptide nucleic acid , polynucleotide , peptide , boron , ribonucleoside , molecular recognition , rna , combinatorial chemistry , biochemistry , organic chemistry , dna , molecule , gene
A novel nucleic acid model using peptide ribonucleic acid (PRNA), which contains 5′‐amino‐5′‐deoxypyrimidine ribonucleoside as a recognition site for nucleic acids, has been designed, synthesized and applied to the external reversible control of recognition behavior of the complementary polynucleotide through the orientational switching of the nucleobase induced by borate. © 2004 Wiley Periodicals, Inc. Biopolymers (Pept Sci), 2004