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Solid‐phase synthesis of C‐terminal modified peptides
Author(s) -
Alsina Jordi,
Albericio Fernando
Publication year - 2003
Publication title -
peptide science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.556
H-Index - 125
eISSN - 1097-0282
pISSN - 0006-3525
DOI - 10.1002/bip.10492
Subject(s) - chemistry , solid phase synthesis , combinatorial chemistry , peptide , terminal (telecommunication) , phase (matter) , peptide synthesis , biomolecule , stereochemistry , biochemistry , organic chemistry , computer science , telecommunications
Solid‐phase synthesis of biomolecules, of which peptides are the principal example, is well established. However, synthetic peptides containing modifications at the carboxy termini are often desired because of their potential therapeutic properties. As a result, there is a necessity for effective solid‐phase strategies for the preparation of peptides with C‐terminal end groups other than the usual carboxylic acid and carboxamide functionalities. The present article primarily reviews literature reports on methods for solid‐phase synthesis of C‐terminal modified peptides. In addition, general information about biological activities and/or synthetic applications of each individual class of peptide is also provided. © 2003 Wiley Periodicals, Inc. Biopolymers (Pept Sci) 71: 454–477, 2003