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Sequence and structure space of RNA‐binding peptides
Author(s) -
Das Chandreyee,
Frankel Alan D.
Publication year - 2003
Publication title -
biopolymers
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.556
H-Index - 125
eISSN - 1097-0282
pISSN - 0006-3525
DOI - 10.1002/bip.10429
Subject(s) - computational biology , sequence (biology) , rna , chemistry , sequence space , binding site , biology , biochemistry , gene , mathematics , pure mathematics , banach space
Studies of RNA‐binding peptides, and recent combinatorial library experiments in particular, have demonstrated that diverse peptide sequences and structures can be used to recognize specific RNA sites. The identification of large numbers of sequences capable of binding to a particular site has provided extensive phylogenetic information used to deduce basic principles of recognition. The high frequency at which RNA‐binding peptides are found in large sequence libraries suggests plausible routes to evolve sequence‐specific binders, facilitating the design of new binding molecules and perhaps reflecting characteristics of natural evolution. © 2003 Wiley Periodicals, Inc. Biopolymers, 2003