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Application of the Suzuki‐Miyaura cross‐coupling reaction for the modification of phenylalanine peptides
Author(s) -
Kotha Sambasivarao,
Lahiri Kakali
Publication year - 2003
Publication title -
biopolymers
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.556
H-Index - 125
eISSN - 1097-0282
pISSN - 0006-3525
DOI - 10.1002/bip.10420
Subject(s) - chemistry , yield (engineering) , phenylalanine , combinatorial chemistry , coupling reaction , organic chemistry , biochemistry , catalysis , amino acid , materials science , metallurgy
We have demonstrated an exceptionally simple and a useful methodology for modification of unusual phenylalanine peptides by adapting the building block approach using the Suzuki‐Miyaura cross‐coupling reaction as a key step. This strategy gave a good overall yield of various modified tri‐ and pentapeptides that may be useful to prepare various biologically active peptides in a short period of time. © 2003 Wiley Periodicals, Inc. Biopolymers 69: 517–528, 2003