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Regulation of the K channels by cytoplasmic domains
Author(s) -
Choe Senyon,
Roosild Tarmo
Publication year - 2002
Publication title -
peptide science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.556
H-Index - 125
eISSN - 1097-0282
pISSN - 0006-3525
DOI - 10.1002/bip.10309
Subject(s) - chemistry , intracellular , potassium channel , alternative splicing , shaker , rna splicing , microbiology and biotechnology , cytoplasm , gene , biophysics , electrophysiology , messenger rna , neuroscience , biology , biochemistry , rna , physics , quantum mechanics , vibration
Abstract Regulation of intracellular potassium levels is one of the basic functions of all cells, controlling cellular osmolarity and transmitting information. In higher organisms, elaborate control of transmembrane potassium flux has evolved to endow nervous systems with the remarkable ability to transmit electrical signals between cells. Multiple genes, gene splicing, mRNA editing, and selective tetrameric assembly of K channel genes provide the basis for creating distinct electrophysiological properties at varying developmental and cellular stages. This assembly mechanism, primarily governed by the T1 domain, is under the control of intracellular signals. Atomic structures of the isolated T1 domains of Shaker and Shaw subfamilies provided us with valuable structural insights into understanding both channel assembly and functional regulation of the entire channel molecule through conformational changes. © 2003 Wiley Periodicals, Inc. Biopolymers (Pept Sci) 66: 294–299, 2002