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Electron microscopy of functional ribosome complexes
Author(s) -
Frank Joachim
Publication year - 2003
Publication title -
biopolymers
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.556
H-Index - 125
eISSN - 1097-0282
pISSN - 0006-3525
DOI - 10.1002/bip.10210
Subject(s) - chemistry , ribosome , context (archaeology) , translation (biology) , electron microscope , biophysics , nanotechnology , computational biology , physics , biochemistry , rna , materials science , biology , optics , paleontology , messenger rna , gene
Cryoelectron microscopy has made a number of significant contributions to our understanding of the translation process. The method of single‐particle reconstruction is particularly well suited for the study of the dynamics of ribosome–ligand interactions. This review follows the events of the functional cycle and discusses the findings in the context provided by the recently published x‐ray structures. © 2003 Wiley Periodicals, Inc. Biopolymers 68: 223–233, 2003