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Effect of biogenic amines on oxidation of farmorubicin by Fenton‐like reagents
Author(s) -
Kruk Irena,
Lichszteld Krzysztof,
AboulEnein Hassan Y.
Publication year - 2002
Publication title -
biopolymers
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.556
H-Index - 125
eISSN - 1097-0282
pISSN - 0006-3525
DOI - 10.1002/bip.10161
Subject(s) - chemistry , reagent , chemiluminescence , quenching (fluorescence) , oxygen , photochemistry , active oxygen , nuclear chemistry , inorganic chemistry , organic chemistry , fluorescence , physics , quantum mechanics
The aim of this study was to investigate the effect of dopa and catecholamines on the generation of oxygen active species during oxidation of farmorubicin by “Fenton‐like” reagents using chemiluminescent and spectrophotometric techniques. The tested catechols were found to reduce the light emission accompanying oxidation of farmorubicin by Co(II) + H 2 O 2 and Cu(II) + H 2 O 2 mixtures. The quenching effect was followed by their rapid oxidation to aminochromes possessing toxic activities. © 2002 Wiley Periodicals, Inc. Biopolymers (Biospectroscopy) 67: 421–427, 2002