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A study of conformational stability of poly( L ‐alanine), poly( L ‐valine), and poly( L ‐alanine)/poly( L ‐valine) blends in the solid state by 13 C cross‐polarization/magic angle spinning NMR
Author(s) -
Murata Katsuyoshi,
Kuroki Shigeki,
Kimura Hideaki,
Ando Isao
Publication year - 2002
Publication title -
biopolymers
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.556
H-Index - 125
eISSN - 1097-0282
pISSN - 0006-3525
DOI - 10.1002/bip.10124
Subject(s) - chemistry , miscibility , trifluoroacetic acid , polymer chemistry , valine , alanine , polymer , magic angle spinning , nuclear magnetic resonance spectroscopy , stereochemistry , organic chemistry , amino acid , biochemistry
13 C cross‐polarization/magic angle spinning (CP/MAS) NMR and 1 H T 1ρ experiments of poly( L ‐alanine) (PLA), poly( L ‐valine) (PLV), and PLA/PLV blends have been carried out in order to elucidate the conformational stability of the polypeptides in the solid state. These were prepared by adding a trifluoroacetic acid (TFA) solution of the polymer with a 2.0 wt/wt % of sulfuric acid (H 2 SO 4 ) to alkaline water. From these experimental results, it is clarified that the conformations of PLA and PLV in their blends are strongly influenced by intermolecular hydrogen‐bonding interactions that cause their miscibility at the molecular level. © 2002 Wiley Periodicals, Inc. Biopolymers 64: 26–33, 2002