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Hydrodynamic properties of rigid macromolecules composed of ellipsoidal and cylindrical subunits
Author(s) -
García de la Torre J.,
Carrasco B.
Publication year - 2002
Publication title -
biopolymers
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.556
H-Index - 125
eISSN - 1097-0282
pISSN - 0006-3525
DOI - 10.1002/bip.10013
Subject(s) - chemistry , macromolecule , ellipsoid , macromolecular substances , biophysics , chemical physics , crystallography , polymer science , physics , biochemistry , astronomy , biology
A procedure is devised for the calculation of hydrodynamic properties of rigid macromolecules composed subunits that are modeled as ellipsoids of revolution and cylinders. Owing to the axial symmetry of these shapes, smooth shell models can be constructured for the subunit structure. The bead shell model so constructed is employed for the calculation of the properties. A computer program, HYDROSUB, has been written implementing both the model building and the hydrodynamic calculation. A detailed example of the use of this methodology is presented for the case of the solution properties of the human antibody molecule immunoglobulin G3 (IgG3). Finally, hints are given on other uses and applications of the procedure. © 2002 John Wiley & Sons, Inc. Biopolymers 63: 163–167, 2002; DOI 10.1002/bip.10013