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Outside Front Cover: Biotechnology Journal 2/2020
Author(s) -
Liu Qian,
Fan Wenjie,
Zhao Yajin,
Deng Zixin,
Feng Yan
Publication year - 2020
Publication title -
biotechnology journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.144
H-Index - 84
eISSN - 1860-7314
pISSN - 1860-6768
DOI - 10.1002/biot.202070021
Subject(s) - nonribosomal peptide , in silico , front cover , computational biology , peptide , starter , biochemistry , chemistry , cover (algebra) , combinatorial chemistry , gene , biology , biosynthesis , engineering , food science , mechanical engineering
The starter C domains (C1) in nonribosomal peptide synthetases (NRPSs) are responsible for fatty acid modification that can strongly affect lipopeptides bioactivity. In article 1900175 Qian et al, present detailed understanding of C1 in the dynamic NRPS system via in silico analysis and subsequently allowing position of specific residues for fatty acyl selectivity, which facilitate NPRS engineering and efforts on novel lipopeptides.