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Recent Advances in Biomaterial‐Based High‐Throughput Platforms
Author(s) -
Sarkar Joyita,
Kumar Ashok
Publication year - 2021
Publication title -
biotechnology journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.144
H-Index - 84
eISSN - 1860-7314
pISSN - 1860-6768
DOI - 10.1002/biot.202000288
Subject(s) - biomaterial , throughput , computer science , nanotechnology , bioprocess , biochemical engineering , materials science , engineering , telecommunications , chemical engineering , wireless
High‐throughput systems allow screening and analysis of large number of samples simultaneously under same conditions. Over recent years, high‐throughput systems have found applications in fields other than drug discovery like bioprocess industries, pollutant detection, material microarrays, etc. With the introduction of materials in such HT platforms, the screening system has been enabled for solid phases apart from conventional solution phase. The use of biomaterials has further facilitated cell‐based assays in such platforms. Here, the authors have focused on the recent developments in biomaterial‐based platforms including the fabricationusing contact and non‐contact methods and utilization of such platforms for discovery of novel biomaterials exploiting interaction of biological entities with surface and bulk properties. Finally, the authors have elaborated on the application of the biomaterial‐based high‐throughput platforms in tissue engineering and regenerative medicine, cancer and stem cell studies. The studies show encouraging applications of biomaterial microarrays. However, success in clinical applicability still seems to be a far off task majorly due to absence of robust characterization and analysis techniques. Extensive focus is required for developing personalized medicine, analytical tools and storage/shelf‐life of cell laden microarrays.